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Regulation of CT Synthesis
CT is released by parafollicular cells in response to increases in plasma ionic calcium. Estrogens, dopamine, glucagon, and beta adrenergic agonists stimulate the secretion of CT. GI hormones such as secretin, gastrin, and cholecystokinin also stimulate CT release. Pharmacologic levels of gastrin, such as with pernicious anemia and gastrinoma (Zollinger-Ellison syndrome), cause an elevation of CT. CT is quickly degraded in the kidney and has a half-life of 10 minutes.
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