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Release of Secretin
The most potent stimulus for secretin release is acidification of the duodenum. Duodenal acidification is the consequence of emptying of the stomach. Secretin release begins when duodenal pH falls below 4.5. At a pH less than 3.0, pancreatic secretion and secretin release are directly related to the load of titratable acid delivered to the duodenum. Fatty acids, particularly oleic acid, are weak stimulants for secretin release. Neither protein digestion products nor carbohydrates cause significant secretin release, nor is a neural mechanism involved. Bile at near neutral pH can cause secretin release, but the physiologic significance remains unclear.
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