Death of a healthy subject in a drug trial (“hexamethonium”) temporarily halted all federally funded research at Johns Hopkins University in 2001.
What is the standard for a comprehensive literature search?
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A comprehensive search is needed for the use of a drug that has not been approved by the Federal Drug Administration (FDA) for use in humans
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Adjust the extent of the literature search to the amount of evidence required to satisfy your research requirements
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MCG has two drug research related sites:
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The primary investigator and the Office of Human Research Protection (OHRP) should approve the adequacy of the literature search
What are the best practice steps for a comprehensive literature search?
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Identify the drug by its class and alternate names
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Consult reference sources
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Consult secondary sources
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Indexing and abstracting services of the primary literature such as Medline, Web of Knowledge including Web of Science (combined databases of both Science Citation and Social Sciences Citation) and Current Contents (see Databases web page)
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Select the sources with the best evidence of safety or adverse effects for the drug and create a bibliography
What are some online reference sources for drug information?
Where can I find Print sources for retrospective drug information in the Greenblatt Library?
Drug Facts and Comparisons (Reference QV 772 .F142)
Physicians’ Desk Reference (Reference QV 772 .P578)
Ellenhorn’s Medical Toxicology (Books QV 600 .E45 1997)
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The Extra Pharmacopoeia/Martindale (Reference QV 738.FA1 M384e)
Quarterly Cumulative Index Medicus (1927 - 1956) (History Reference)
Index Catalogue of the Library of the Surgeon General (1873-1948 History Reference)
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Science Citation Index (1961 – 2000) [Note: use Web of Knowledge to search this content online from 1977 – present]
The Department of Pharmacy maintains the MCG Health System Formulary searchable by keyword, alphabetically, or by therapeutic category. Drug information is also available from the department’s homepage from LexiComp Online and AHFS Drug Information (from AHFSfirst Web). Access to Department of Pharmacy drug information products is restricted to on-campus or to pharmacy personnel. The Greenblatt Library’s Drug Information web page lists additional resources and links to the Department of Pharmacy homepage.
